If you’re struggling with depression, you may notice that no matter how much sleep you get, you still feel exhausted. Fatigue is one of the most common symptoms of depression, but why does depression make you so tired? In this article, we’ll explore the reasons behind depression-related fatigue and what you can do about it.
1. Depression Affects Brain Chemistry
Depression disrupts the balance of neurotransmitters in the brain, particularly serotonin, dopamine, and norepinephrine. These chemicals play a crucial role in mood regulation, motivation, and energy levels. When their levels are low, it can lead to feelings of exhaustion, sluggishness, and a lack of motivation to do even simple tasks.
2. Sleep Disturbances and Depression
Depression often interferes with sleep, leading to insomnia or excessive sleeping (hypersomnia). Many people with depression experience trouble falling asleep, waking up frequently during the night, or waking up too early and being unable to go back to sleep. Poor sleep quality contributes to persistent fatigue, making it hard to feel rested, no matter how long you sleep.
3. Increased Stress Hormones
Drain Your Energy Depression is linked to higher levels of cortisol, the stress hormone. When cortisol levels remain elevated for long periods, it can lead to chronic fatigue, muscle weakness, and difficulty concentrating. Your body remains in a constant state of stress, which can be physically and mentally draining.
4. Low Motivation and Physical Activity
When you’re depressed, it’s common to lose interest in activities you once enjoyed. A lack of physical activity can contribute to lower energy levels. Exercise is known to boost endorphins and improve energy, but depression can make it feel impossible to get moving, creating a cycle of fatigue.
5. Poor Diet and Nutritional Deficiencies
Depression can impact your appetite, leading to either overeating or undereating. Nutritional deficiencies, such as low iron, vitamin D, or B vitamins, can make you feel exhausted. A diet high in processed foods and sugar can also cause energy crashes, making fatigue even worse.
6. Emotional Exhaustion Wears You Down Depression isn’t just physically exhausting—it’s emotionally draining. Constant negative thoughts, feelings of hopelessness, and overwhelming sadness take a toll on your mental energy. This emotional exhaustion can make even the smallest tasks feel like monumental challenges.
7. Underlying Medical Conditions
Depression is sometimes linked to other health conditions that contribute to fatigue, such as thyroid disorders, chronic fatigue syndrome, or anemia. If you’re experiencing extreme tiredness that doesn’t improve, it may be helpful to consult a doctor to rule out any underlying medical issues.
How to Fight Depression-Related Fatigue
While overcoming fatigue from depression can be challenging, there are steps you can take to improve your energy levels:
- Improve Your Sleep Hygiene: Stick to a regular sleep schedule, avoid screens before bed, and create a relaxing nighttime routine.
- Stay Active: Even small amounts of movement, like a short walk, can boost energy and mood.
- Eat a Balanced Diet: Focus on whole foods, lean proteins, and nutrient-rich fruits and vegetables.
- Manage Stress: Practices like mindfulness, meditation, and deep breathing can help reduce cortisol levels.
- Seek Professional Help: Therapy and, in some cases, medication can help regulate brain chemistry and improve energy levels.
Final Thoughts
Depression-related fatigue is real, and it can make daily life feel overwhelming. Understanding the connection between depression and tiredness is the first step toward finding relief. If you’re struggling with persistent fatigue, seeking support from a therapist or healthcare provider can make a significant difference in managing your symptoms and improving your quality of life.
If you’re looking for therapy for depression, Authentic Living London offers compassionate, evidence-based support to help you regain your energy and well-being.
Contact us today to learn more about how therapy can help.

Sandra Graham, one of our therapists here at Authentic Living London, specializes in depression and mood disorders. To learn more about Sandra please click HERE.